The Diagnosis and Treatment of Male Infertility by Nabil Aziz & Ashok Agarwal

Author:Nabil Aziz & Ashok Agarwal
Language: eng
Format: epub
Publisher: Springer International Publishing, Cham

Conclusion

KS is a common chromosomal abnormality imposing significant effects on patients’ overall health and fertility. It is characterized by hypergonadotropic hypogonadism and testicular failure, which appears to be progressive in nature with relatively better testicular function witnessed among younger boys. Early treatment of adolescents is thus recommended to overcome the negative influences of hypogonadism. Adolescents interested in fertility should be asked to provide a semen sample and should be offered sperm cryopreservation. However, invasive procedures are impractical and costly and can have negative consequences, especially on hormone levels. Adult sperm retrieval is promising with reported success rates as high as 70%. Pretreatment medical therapy delivers superior results with a potential advantage to anastrozole. Couples concerned about the transmission of chromosomal abnormality to their offspring may be offered PGD during ICSI.

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